Secondary Teachers’ Descriptions of Blended Learning and Professional Development: A Case Study

Teachers who were born before the proliferation of computers are a large part of the education workforce. Therefore, it is important to understand how that group of teachers describes the use of technology in their classroom, as well as professional development that they have taken which focused on the implantation of blended learning in their classrooms. The purpose of the qualitative descriptive single case study was to understand how teachers describe technology and blended learning in their classrooms, as well as their descriptions of professional development that focuses on technology regarding blended learning. The overlying research question for the study was how teachers who were born outside the digital age describe technology as it related to blended learning. The underlying research questions were how do teachers describe professional development that focusses on technology and blended learning, and how do teachers describe the use of blended learning in their classroom? The sample included secondary teachers who were born outside of the digital age who taught in an urban school district. Data collection was done in three parts: an online questionnaire, semistructured interviews, and filed notes. The results of this study described how teachers who were born outside of the digital age use technology with their classes, and how professional development has influenced the implementation of blended learning in their classes. Recommendations for future practice with professional development are presented

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV

Informing via Research: Methods, Challenges and Success when Using a Multi-Disciplinary Team and Reverse Engineering Analysis Processes to Answer a 200 Year Old Question

The goal of this study was to develop the foundation for the creation of a 21^st century spiritual which could be used to mitigate the effects of stress and violence. Using a multi-disciplinary team and basing the work in the music of the antebellum Negro Spiritual (a group of 6000 works), reverse engineering, extensive use of engineering principles and utilization of existing databases was done to aid in the analysis of the neurological and physiological impact of the musical form and development of an applicable theory